While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. "I started the hydroxychloroquine medication a week ago and within the first day or two noticed a big difference in my pain and fatigue with major improvement SLE. Non malarial uses of chloroquine Can i take amitriptyline with plaquenil Plaquenil side effects on liver Reviews on plaquenil I have actually had this same reoccurring rash for about 5 years, but wasn't diagnosed with lupus until earlier this year. So mine is def not caused by the Plaquenil. My doc cannot find the connection, but the only thing that helps me is Zyrtec I use the generic. I hope this at least helps you find relief with the rash. Hydroxychloroquine is a one of a number of drugs which have been used for many years in the treatment of malaria. Fortunately, it was discovered these drugs often are helpful in the treatment of various rheumatic diseases, particularly systemic lupus erythematosus SLE or "Lupus" and rheumatoid arthritis. It does not appear to be from the Plaquenil but, simply Lupus. Don't mean to scare you but, this can be caused by Plaquenil OR by Lupus OR M. S. Don't wait to have your eyes checked out if you are having any vision issues or the doctor sees an issue. I have been getting these horrible rashes and they are not related to sun exposure. I am interested to see if anyone here has gotten a rash from Plaquenil after being on it for several months. Plaquenil for lupus rash Terrible Itching on Plaquenil---PLEASE HELP., Plaquenil. A medication for Lupus Plaquenil reduction Plaquenil is also known by its drug name, Hydroxychloroquine. Plaquenil may be prescribed at a low dose for maintenance, or at a high dose to control acute flare-ups. Plaquenil is a disease-modifying drug originally developed to treat malaria. Plaquenil is believed to work by interfering in communication between the cells of the immune system. Plaquenil Hydroxychloroquine MyLupusTeam. Immune & Autoimmune - Lupus How long do your malar rashes.. Lupus - Symptoms and causes - Mayo Clinic. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. However, following an identical dose of. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. To treat lupus erythematosus, the average adult dose is 400 mg once or twice daily. What Drugs, Substances, or Supplements Interact with Plaquenil? These medications may also prevent lupus from spreading to certain organs, such as the kidney and central nervous system your brain and spinal cord and may help to reduce flares by as much as 50%. Plaquenil and other anti-malarials are the key to controlling lupus long term, and some lupus patients may be on Plaquenil for the rest of their lives.