If so, would you share a comment on the experience you have had with methotrexate; & the length of time on the medication, benefits noted, and side effects. It can be brief or as detailed as you desire to describe your experience. I used plaquenil for some time on its own, then added in MTX before changing over to leflunomide. Chloroquine tablet price Mechanism of action of hydroxychloroquine in diabetes Hyperpigmentation plaquenil Plaquenil made from what root Does anyone use methotrexate just for their Sjogrens symptoms? If so, would you share a comment on the experience you have had with methotrexate; & the length of time on the medication, benefits noted, and side effects. Sjogren's Syndrome Support. Methotrexate opinions. Symptoms and Medical Treatments _Lisa_D. I used plaquenil for some. Sep 05, 2016 I think the Plaquenil is still helping me, but for whatever reason my Sjogren's is just getting more aggressive lately. If a doctor wants to give you a medicine, then they think it might help you. You should at least give it a try. There is no "cure" for Sjogren's at least not yet and medicine won't magically make all your symptoms go away. Some patients develop a cough or low grade fever. Rarely, a pneumonia-like syndrome can complicate treatment. Methotrexate can be irritating to the liver. Patients taking methotrexate should avoid drinking alcohol and need to have liver function tests performed by their physician on a regular basis. I would have stayed on MTX if it worked for me, but it didn’t. I didn’t drop plaquenil until I had been on a biologic for about six months. Plaquenil and methotrexate for sjogren's syndrome Reasonably Well Gastrointestinal Effects of Sjogren's Syndrome, Plaquenil - General - Sjogren's Syndrome Support Using plaquenil in end stage macular degenerationPlaquenil breastfeeding category It’s used in people with Sjogren’s syndrome, rheumatoid arthritis, and lupus to relieve joint pain, fatigue, and rashes. It may take up to 12 weeks for you to notice the effects of hydroxychloroquine. Hydroxychloroquine is safe, even for pregnant women with Sjogren’s syndrome. Medications for Sjogren’s Syndrome NYU Langone Health. Methotrexate and its benefit for Sjögren’s patients. Sjogren's diagnosis - prescribed Plaquenil?. Hydroxychloroquine Plaquenil, a drug designed to treat malaria, is often helpful in treating Sjogren's syndrome. Drugs that suppress the immune system, such as methotrexate Trexall, also might be prescribed. Plaquenil hydroxychloroquine "I’ve been on plaquenil 400mg once a day for 6 months now due to Sjogrens. If your are wondering how long the plaquenil takes to work, it took about 3 months before I starting feeling better. Hi there, I did have a loss of appetite on plaquenil, but not in a good way. It was nausea, dizzy spells and anxiety. I am one of the few that had a hard time tolerating it, so I no longer take it.