My peripheral neuropathy actually went away too, and my rheumy thinks it was a rare, toxic side-effect of the Plaquenil. Get emergency medical help if you have any of these signs of an allergic reaction while taking hydroxychloroquine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Fatigue is part of malaria, which is the normal use of this medication. Plaquenil pictures Hydroxychloroquine sulfate drug interactions Methylprednisolone and hydroxychloroquine Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Can Plaquenil cause Muscle Weakness? Muscle Weakness is a known side effect of Plaquenil. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Jun 25, 2013 Muscle damage and leg pain being just 2 examples. It is great that you have responded so well to the new medication. I haven't taken either of these medications, but it thought it may help to know that the symptoms you experienced are common, so the discontinuation of Plaquenil could indeed improve these areas. This is not a complete list of side effects and others may occur. Call your doctor at once if you have a serious side effect such as:muscle weakness, twitching, or uncontrolled movement;loss of balance or coordination;blurred vision, light sensitivity, seeing halos around lights;pale skin, easy bruising or bleeding;confusion, unusual thoughts or behavior; orseizure (convulsions). Less serious side effects of hydroxychloroquine may include:headache, ringing in your ears, spinning sensation;nausea, vomiting, stomach pain;loss of appetite, weight loss;mood changes, feeling nervous or irritable;skin rash or itching; or hair loss. Plaquenil and muscle relaxor Muscle relaxers? -, Can Plaquenil cause Muscle Weakness? - Treato Is plaquenil safe to take while breastfeeding Medscape - Indication-specific dosing for Plaquenil hydroxychloroquine sulfate, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Plaquenil hydroxychloroquine sulfate dosing, indications.. Hydroxychloroquine - thigh muscle weakness?. Will muscle relaxers help joints?" Lupus Community.. I've been taking Plaquenil 400 mg for nearly 6 mos. I didn't seem to have any problems whatsoever with it initially, other than very short term and mild cramping/diarrhea. But now I've been dealing with considerable muscle aching and pain/spasm in some new places - or at least places that haven't bothered me in quite awhile. With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. For this reason though, it is important that you see an ophthalmologist for an exam before starting to take an anti-malarial medication for your lupus. Find information about common, infrequent and rare side effects of Plaquenil Oral.