I do have anxiety disorder but have not had a panic attack in two years and certainly not waves of panic. I have since lost my appetite and can only eat a little. Hydroxychloroquine and skin rash Chloroquine phosphate structure Lysotracker chloroquine Hi, i beleive Dmards can take up to 3 months to kick in so may take a bit longer to kick in. I started Hydroxychloriquine 400mg and steroids when i was first diagnosed and remember thinking 'are these tablets supposed to be doing something'. I think after about 2 weeks i felt a lot better but that was with steroids. Annalouk, I don't think that 9 weeks is enough time to say it is not working. I started on Prednisone and Hydroxychloroquine on the same day, it took 3 months on prednisone tapering for rash to settle down and another 3 months before I could really say the the Hydroxychloroquine was helping. It takes 3 months for this drug to begin to work like it should in your body. It also takes 3 months for it to be completely out of your system once you quit taking it, according to my rheumatologist. This didn't make me happy because I really feel that looking for more medication from someone else for sudden symptoms is not a wise choice. It helped me sleep but makes me way too tired during the day -- so it is like I am anxious, panicky, and exhausted now. She said right away that she does not think it is the plaquenil and then suggested I see a psychiatrist. How long until hydroxychloroquine works Taking Plaquenil for Rheumatoid Arthritis, How long did hydroxychloroquine take to work. - HealthUnlocked Plaquenil false positive thcHydroxychloroquine retina To treat malaria Hydroxychloroquine is usually given for 3 days, starting with one high dose followed by a smaller dose during the next 2 days in a row. Take this medicine for the full prescribed length of time for malaria. Your symptoms may improve before the infection is completely cleared. Hydroxychloroquine Uses, Dosage & Side Effects -. How long does it take for plaquenil to leave your system?. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. How long will I need to take hydroxychloroquine before I see an effect? Hydroxychloroquine does not work immediately. It may be 12 weeks or longer before you notice any benefit. When should I take hydroxychloroquine? You should take hydroxychloroquine with or after food. Given the drug’s many and varied beneficial effects and its excellent long-standing safety profile, most rheumatologists believe that hydroxychloroquine should be taken by people with lupus throughout their lifetime. Annual examinations with a qualified retina specialist are strongly encouraged, however. Hydroxychloroquine along with 30 mg of Prednisone worked for me within 3 months and did a great job. However I had a side reaction- hallucination, so I came off the drug. Plaquenil did not work as well for me,it took about 10 weeks before I saw some effect but again I had a reaction- my fatigue got even worse and I could not stay awake.