The reaction can be phototoxic and/or photoallergic. Phototoxic reactions result from direct damage to tissue caused by light activation of the photosensitising agent, whilst photoallergic reactions are a cell-mediated immune response in which the is the light-activated photosensitising agent. Plaquenil method of action Chloroquine santa cruz Plaquenil time to work Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Plaquenil and Photosensitivity reaction - a real-world study. Summary Photosensitivity reaction is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 6 - 12 months, also take medication Humira, and have Pain. Once we determined that Plaquenil was worsening my psorasis to affect my nails and tendon inserts, I came off it for good. Skin rashes occasionally develop and hydroxychloroquine may make you more sensitive to the sun, so it is advisable to use the usual precautions of sunscreens and a hat if you are in the sun. Although some oral photosensitising medications can cause photoallergic reactions, most cause phototoxic reactions. Photoallergic reactions occur less commonly than phototoxic reactions and are mostly caused by photosensitising topical agents. Plaquenil and photosensitivity Hydroxychloroquine ~ sun sensitivity? Hi everyone. - LUPUS UK, Will you have Photosensitivity reaction with Plaquenil. Mechanism plaquenilHydroxychloroquine 200 mg tabletFaf in plaquenil toxicityHydroxychloroquine interactionsWhere is chloroquine resistant malaria Plaqunil rash. Support Forums Lupus New Topic Reply. Plaquenil has beneficial effects on 3 major aspects of lupus; skin rashes, aches & pains and fatigue. It has also been found to help in a number of other features of the disease, though less predictably. It is very effective in the treatment of a whole variety of lupus skin rashes. Plaqunil rash -. Plaquenil and the sun - Sarcoidosis - Inspire. Plaquenil and Sun Exposure - Sjogren's World. Plaquenil is generally agreed to reduce photosensitivity a little, so that it is an extra help, but not so much that other precautions can be relaxed. In a very few people it can cause a photosensitive reaction, by a different sort of mechanism, which cancels out the protective element. If you have lupus, protecting yourself from sun exposure is an essential part of managing your people with lupus experience photosensitivity or unusual sensitivity to sunlight. This. I've read on medical sites that Hydroxychloroquine can react with the sun causing allergic reactions and I wonder if this is the cause of the rash on this occasion or whether it's just my normal photosensitivity. I've read some posts on the forum here about people reacting to Hydroxychloroquine but it seems to be very severe as you say twitchytoes.