Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Hydroxychloroquine vs hydroxychlor Plaquenil hydroxychloroquine and lupus Oct 01, 2018 Use of Chloroquine phosphate tablets for indications other than acute malaria is contraindicated in the presence of retinal or visual field changes of any etiology. Use of Chloroquine phosphate tablets is contraindicated in patients with known hypersensitivity to 4-aminoquinoline compounds. Warnings. Chloroquine-Resistant Malaria Aug 30, 2011 Chloroquine and hydroxychloroquine both belong to the quinolone family and share similar clinical indications and side effects, including retinal toxicity. Chloroquine-induced retinal toxicity was first described in 1959 and the retinal toxic effects of hydroxychloroquine were later described in 1967 3, 4. Different effects of chloroquine and hydroxychloroquine on lysosomal function in cultured retinal pigment epithelial cells Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Chloroquine retinal cell Common Medications That May Be Toxic to the Retina, Hydroxychloroquine Plaquenil Toxicity and Recommendations. Is plaquenil bad for your eyesPlaquenil retinal toxicity guidelinesHydroxychloroquine metforminChloroquine and filipina clathrin mediated endocytosis Side effectsManagementGoalsMechanismPrognosisPathophysiologyToxicityPreventionInteractionsGeneticsPurposeMedical usesAnalysisResearchDiagnosisSecurityResourcesContraindications Recommendations on Screening for Chloroquine. Different effects of chloroquine and hydroxychloroquine on.. Expanded spectral domain-OCT findings in the early detection.. Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. Chloroquine should not be used in these conditions unless the benefit to the patient outweighs the potential risks. People with retinal or visual field changes should not use chloroquine unless it is absolutely necessary. Some strains of P. falciparum are resistant to chloroquine and hydroxychloroquine. Chloroquine resistance is widespread.