The most common side effect associated with its use is retinal toxicity, which may be irreversible. Therefore, it is pertinent to know the findings, risk factors, and screening tests necessary to prevent retinal damage. Chloroquine vs hydroxychloroquine Chloroquine paludisme Aug 01, 2009 Everything is dark inside and outside is so bright the it is painful to open my eyes. Plaquenil toxicity is not reversible in most cases and continues to progress even after you stop taking it for several month and sometimes years because of the half life of Plaquenil One should see a retina special before taking Plaquenil in my opinion Jun 11, 2009 Deferoxamine toxicity is reversible with drug cessation, with full recovery of visual function. However, the medication is often used for chronic conditions, such as thalassemia, that require regular therapy. In these patients, monitoring with frequent ophthalmic exams is essential to detect early vision loss. This condition does not cause symptoms and is reversible with cessation of the medication. The finding of corneal verticillata bares no correlation with retinal toxicity and is not an indication to stop the medication. The hallmark of hydroxychloroquine toxicity is bilateral pigmentary retinopathy. Patients with early retinal findings are often asymptomatic despite having subtle paracentral scotomas. During the first five years of use, the rate of toxicity was found to be 0.7%, rising significantly to more than 1% after five to seven years of use. The prevalence of retinal toxicity has varied among different studies. Is plaquenil retinal toxicity reversible Evaluation of Hydroxychloroquine Retinopathy With Multifocal., Common Medications That May Be Toxic to the Retina Plaquenil testing protocolPlaquenil lupus remissionHydroxychloroquine sulfate and alcohol Hence, it is imperative that we become familiar with recognizing the spectrum of HVF and SD-OCT findings associated with Plaquenil retinal toxicity. Of note, SD-OCT, in combination with Humphrey visual field testing, is critical for the early detection of Plaquenil retinal toxicity. How to Succeed in Plaquenil Screenings. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Retinal Physician - Retinal Toxicities Caused by Systemic.. Feb 19, 2020 What Is Plaquenil? Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. The reader's question and comment prompted me to do a little more research on the question of whether plaquenil toxicity was reversible which led me to the results of this study, which was published in JAMA Opthamology Jan 2011-- the same month and year as the Sjogren's Syndrome Foundation article was published. The study authors concluded "Sustained visual improvement following cessation of drug therapy was not observed in any patient in this series, and our identification of 6 patients. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. While today it is used to treat autoimmune conditions, such as rheumatoid arthritis and lupus, it was originally used as an anti-malaria drug.