Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Does hydroxychloroquine cause diarrhea Plaquenil is os jumction Does hydroxychloroquine get you high Plaquenil Side Effects of Anxiety and Depression? I've been on plaquenil for a very long time - maybe 15 years. I saw a new rhuemie today who said I should take a break & see how I feel with some anti-inflammatories, a good diet, exercise and rest. Hi! I think Plaquenil is the cause of my extreme fatigue too. I am not anemic at this time and I get exhausted just trying to get through the day. I have also been on Plaquenil about three months. All of my arthritis swelling and pain are gone, but the fatigue will not let up! Hope things change for you. Anxiety, depression and suicidal ideation in patients with rheumatoid arthritis in use of methotrexate, hydroxychloroquine, leflunomide and biological drugs. Pinho de Oliveira Ribeiro N1, Rafael de Mello Schier A, Ornelas AC, Pinho de Oliveira CM, Nardi AE, Silva AC. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil and depression Anxiety and Plaquenil Has anyone experienced mood., Is extreme fatigue a side effect of Plaquenil? Low dose of plaquenilChloroquine and anti-kellHydroxychloroquine inrPlaquenil pregnancy apsPlaquenil testing Depression can be a common manifestation in people with lupus. It is often difficult to determine whether the depression is an integral part of lupus as it is in some patients, where management of the lupus itself often lifts the depression, whether the depression has arisen in response to having a chronic painful illness. Lupus and Depression - LUPUS UK. Anxiety, depression and suicidal ideation in patients with.. Plaquenil - Uses, Side Effects, Interactions -. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage is also based on weight. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form.