Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine: Incidence not known Some side effects of chloroquine may occur that usually do not need medical attention. Chloroquine ph 250 mg tablet Plaquenil side effects fluid retention What does hydroxychloroquine treat Jan 05, 2020 Hydroxychloroquine toxicity Disease Entity. Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity. Diagnosis. For retinopathy, patients should be asked about poor central vision. Management. At the first signs of retinal toxicity, hydroxychloroquine should be stopped. Chloroquine and hydroxychloroquine both belong to the quinolone family and share similar clinical indications and side effects, including retinal toxicity. Chloroquine-induced retinal toxicity was first described in 1959 and the retinal toxic effects of hydroxychloroquine were later described in 1967 3, 4. Chloroquine and hydroxychloroquine can cause toxic retinopathy due to their binding of melanin in the retinal pigmented epithelium RPE as well as direct toxicity to retinal ganglion cells. Early findings include mottling of the RPE and blunted foveal reflex. As the retinopathy progresses, a bull's-eye maculopathy develops, as seen in these photos. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Chloroquine eye toxicity Hydroxychloroquine Plaquenil Toxicity and Recommendations., Hydroxychloroquine Plaquenil Toxicity and. Chloroquine inhibits dnaPlaquenil prevent antiphosphilipudPlaquenil medication classPlaquenil for celiacPlaquenil bad dreams By 2/2010 things were so dim I could not see to shop in stores. I quit taking Plaquenil but the DR still said no toxicity. My eyes continued to get worst. In tears I went back in July he finally sent me to a retina specialist. You don't have to have Bulls eye damage to have toxicity Over weight women over 60 should beware of taking Plaquenil. Has anyone experienced plaquenil toxicity with damage to eyes?. Bull's-eye maculopathy due to hydroxychloroquine toxicity. My Take on New Ocular Screening Guidelines for Plaquenil.. Color photograph of left eye documenting end-stage chloroquine retinal toxicity, with disc pallor, vascular attenuation, diffuse pigment mottling, and pigment deposition along the peripheral retinal vessels similar to retinitis pigmentosa. Visual acuity was 20/200. Of cells at the back of the eye. This is known as retinal toxicity or retinopathy. Overall, around seven patients out of every 100 taking hydroxychloroquine for more than five years may develop retinopathy that can be detected with specialised tests. The risk is much higher in patients who have been taking the drug for 20 years or more. In these The usefulness of hypokalemia as an indicator in the evaluation of chloroquine toxicity was studied in a retrospective series of 191 acute chloroquine poisonings. Results indicated that the risk of severe poisoning and death are proportional to the degree of hypokalemia.