Chloroquine phosphate for lupus

Discussion in 'Canada Pharmaceuticals Online' started by avsilver, 15-Mar-2020.

  1. atributz XenForo Moderator

    Chloroquine phosphate for lupus


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Contraindications Hypersensitivity to hydroxychloroquine, chloroquine, or 4-aminoquinolines Precautions Use caution in hepatic disease, psoriasis, and porphyria. Reports suggest that antimalarials may exacerbate psoriasis, but they were often safely used to treat psoriatic arthritis. G chloroquine phosphate 600 mg base orally once a day for 2 days, followed by 500 mg chloroquine phosphate 300 mg base orally once a day for at least 2 to 3 weeks

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Chloroquine phosphate for lupus

    Aralen chloroquine Malaria Drug Side Effects & Dosage, Hydroxychloroquine and Chloroquine Phosphate - RheumaKnowledgy

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  5. Irreversible retinal damage observed in some patients; significant risk factors for retinal damage include daily doses of chloroquine phosphate 2.3 mg/kg of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some concomitant drug products such as tamoxifen citrate, and concurrent macular disease.

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    Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Chloroquine is an aminoquinoline used for the prevention and therapy of malaria. It is also effective in extraintestinal amebiasis and as an antiinflammatory agent for therapy of rheumatoid arthritis and lupus erythematosus. Chloroquine is not associated with serum enzyme elevations and is an extremely rare cause of clinically apparent acute liver injury. Aside from preventing and treating malaria, chloroquine is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus.

     
  6. viktor- New Member

    Summary Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Fetal hemoglobin - Wikipedia Fetal Hemoglobin is increased in hemoglobinopathies Hemoglobin Hb, Fetal, Quantitative LabCorp
     
  7. vasinet XenForo Moderator

    Plaquenil - @Destiny1290 - Arthritis - 20150108 - Inspire Jan 08, 2015 I've been taking 400 mgs of Plaquenil for 4 years for RA, Sjogren's Syndrome, UCTD, Raynaud's, etc. It doesn't help a LOT, but it helps enough that if I stop taking it I notice a bad flare. My worst joints are also my hands and wrists, though my hips, spine, feet, toes, ankles and shoulders have joined the party now.

    How Lupus Affects the Lungs Johns Hopkins Lupus Center