One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Foods to avoid while taking plaquenil How to stop taking plaquenil 200 mg of plaquenil how long to work Plaquenil cause constipation Hydroxychloroquine HCQ trade name, Plaquenil and chloroquine CQ trade name, Aralen are drugs established in the treatment of autoimmune disease and skin disorders, but are also emerging as a treatment option in oncology and paediatric inflammatory disorders. In fact, the aPL 1st may contribute to the pathogenesis of premature atherosclerosis in SLE, but 2nd they are also the serologic markers of APS, and therefore, of Hughes’ retinopathy. Figure 1 illustrates better the relationships between the most important mechanisms of retinopathy in SLE. Ocular symptoms of retinopathy include blurred and partial loss of central vision, side vision and in the later stage, night vision. Symptoms of corneal deposits include haloes and glare. Clinical research has resulted in precise screening protocols and safe dosing guidelines to prevent ocular toxicity and detect retinal damage at an early stage. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil retinopathy pathogenesis Hydroxychloroquine retinopathy A review of imaging, Retinopathy in systemic lupus erythematosus pathogenesis and. Is mefloquine a chloroquineChloroquine as antiinflammatory Jan 23, 2017 Furthermore, diabetic retinopathy DR is the most common cause of blindness in middle-aged subjects, accounting for at least 12,000 new cases in the United States each year. Visual loss from DR may be secondary to macular edema retinal thickening and edema involving the macula, hemorrhage from new vessels, retinal detachment, or neovascular. Diabetic retinopathy Pathogenesis - UpToDate. Chloroquine And Hydroxychloroquine Toxicity - StatPearls.. Plaquenil Uses, Dosage & Side Effects -. Pigmentary Retinopathy; Porphyria; Prolonged QT Interval On EKG; Seizures; Skin Rash With Sloughing; Suicidal Behavior; Torsades De Pointes, A Type Of Abnormal Heart Rhythm Blood flow studies have shown that in diabetes the retinal blood flow increases markedly with progress of background retinopathy, decreasing finally where proliferative retinopathy, with marked arteriolar narrowing, is present. On the basis of these findings a working hypothesis for the pathogenesis of diabetic retinopathy is presented. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.