Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil and heart rate Ana and plaquenil Although there are few drug interactions with hydroxychloroquine, to be safe be sure to tell your doctor about all of the medications you are taking, including over-the-counter drugs and natural remedies. Be sure to notify your other physicians when taking this drug. This drug does not have a strong effect We would like to show you a description here but the site won’t allow us. Drug interactions are reported among people who take Prednisone and Hydroxychloroquine sulfate together. This study is created by eHealthMe based on reports of 3,854 people who take Prednisone and Hydroxychloroquine sulfate from Food and Drug Administration FDA, and is updated regularly. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Hydroxychloroquine drug interactions Hydroxychloroquine Interactions BNF content published by NICE, Hydroxychloroquine retinopathy riskPlaquenil prototypeChloroquine side effects usmlePlaquenil cause fungal infectionPlaquenil with zyban Digoxin, cyclosporine, and certain beta blockers may cause drug interactions with hydroxychloroquine. This eMedTV segment explores what may happen if these drugs are taken with hydroxychloroquine and lists other drugs that may cause an interaction. Drug Interactions With Hydroxychloroquine. Prednisone and Hydroxychloroquine sulfate drug interactions.. Hydroxychloroquine MedlinePlus Drug Information. Additional AEs known to be associated with hydroxychloroquine are described in the FDA-approved Full Prescribing Information for Plaquenil. 9. Drug Interactions. Hydroxychloroquine is metabolized in the liver, primarily by CYP2C8 and CYP3A4 enzymes. Drugs that inhibit CYP3A4 enzymes may increase plasma levels of hydroxychloroquine. Hydroxychloroquine belongs to a group of medications known as anti-inflammatories and antimalarials. It is used alone or in combination with other anti-arthritic medications to treat rheumatoid arthritis. It helps to reduce pain, stiffness, and swelling in joints. Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America.