I currently take 6 tablets a week and I started taking them in February this year . Has anyone been through the same as me, and find that the meds simply haven't worked so you have to simply start again. I have called my nurse specialist but she hasn't got back yet. Hang in there- it's very early days x I'm afraid Jacki08 is right it's early days and these meds take time. I am still in a lot of pain I have immense fatigue and feel miserable. I started MTX in September along with naproxen and gradually built up to 8 tablets (20mg) a week by the end of December. Hydroxychloroquine usmle How does plaquenil affect the eyes Dosage Hydroxychloroquine Plaquenil® is the drug of choice among antimalarials. Chloroquine is not commonly used because of greater toxicity on the eye. Chloroquine is not commonly used because of greater toxicity on the eye. Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria chloroquine-resistant. The United States Center for. Aug 26, 2016 Kim3 August 26, 2016, am #1 I’ve been on all of the above and yet nothing seems to work without miserable side effects. The Benlysta made me vomit, the steroids, well, we all know how bad they are, and I’ve been on plaquenil seemingly forever. Things have been in their stride since mid February and now it's looking good regarding fatigue, swelling and pain (though I only ever had a little pain compared to what others have described). I started taking mthx in October last year and expected results quite quickly. Hydroxychloroquine not working what next Hydroxychloroquine Side Effects, Dosage, Uses, and More, Hydroxychloroquine Oral Uses, Side Effects, Interactions. Hydroxychloroquine kidney functionChloroquine phosphate toxic Re Plaquenil not working anymore Lizzy, I took 400mg 200 twice a day for 16-18 months forget exact duration, then was reduced to 200 mg daily. But right from the start, I also needed NSAID's for pain. Immune & Autoimmune - Lupus Plaquenil not working anymore. Benlysta, prednisone, plaquenil. Now what? - General.. What step comes after plaquenil?. Hi ya, I remember the frustration at the beginning, they started me on 8 tablets, didn't do much for 4 months so upped me to 10, after another 3-4 months it did start to help watch out for mouth ulcers, mine were horrendous, needed 6 x folic acid tablets a week to keep them at bay. User Reviews for Hydroxychloroquine to treat Rheumatoid Arthritis. The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care. Quinacrine Atabrine is another alternative, but it is prescribed less often because it can sometimes cause a yellow discoloration of the skin. It is sometimes given in addition to hydroxychloroquine if the patient does not respond to Plaquenil alone.