She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. Plaquenil and inflammation Chloroquine treatment and virus infection Chloroquine resistant malaria countries Chloroquine and its derivative, hydroxychloroquine sulfate, which have been useful in treating malaria and in larger doses, collagen-vascular disease, cause a cumulative dose-related pigmentary retinopathy. Fundus - pigmentry changes, vascular attenuation & optic disc pallor Toxicity is more dependent on total daily dose than on cumulative. Hydroxychloroquine is a well-tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity1. Within the eye, hydroxychloroquine can adversely impact the cornea, ciliary body, and retina1 Purpose To determine the sensitivity of spectral domain ocular coherence tomography SD-OCT and fundus auto fluorescence FAF images as a screening test to detect early changes in the retina prior to the onset of chloroquine retinopathy. Method The study was conducted using patients taking chloroquine CQ, referred by the Rheumatology Department to the Ophthalmology Department at. Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Fundus in chloroquine Chloroquine Professional Patient Advice -, Hydroxychloroquine toxicity - EyeWiki Surgery while taking plaquenilCan you take glucosamine with plaquenilPlaquenil side effects on heartHydroxychloroquine and citrus Most patients are now screened with OCT, visual field testing, and fundus examination. Amsler grid and color vision testing may also be used. Retinal damage from chloroquine and hydroxychloroquine is often irreversible. References. Elman A, Gullberg R, Nilsson E, Rendahl I, Wachtmeister L. Chloroquine retinopathy in patients with rheumatoid. Spotlight Case Chloroquine - The American Society of.. Fundus auto fluorescence and spectral domain ocular.. Chloroquine Aralen - Side Effects, Dosage, Interactions.. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Retinal toxicity from chloroquine has been recognized for decades. 1 The use of its analogue, hydroxychloroquine, has largely replaced chloroquine in most parts of the world, particularly in the. Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.