It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Plaquenil malaria prophylaxis Chloroquine prophylaxis pregnancy Plaquenil pharmacology Rheumatoid Arthritis The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. Hydroxychloroquine for Rheumatoid Arthritis; What are hydroxychloroquine Plaquenil and chloroquine Aralen? These medications are in a class of medications called Disease Modifying Anti-Rheumatic Drugs, or DMARDS. DMARDs are a slow acting but effective treatment for rheumatoid arthritis and other forms of inflammatory arthritis. Dosage While in some cases, lower doses of NSAIDS are effective, in rheumatoid arthritis and other forms of inflammatory arthritis a higher dose is often required to decrease inflammation. A lower dosage can initially be used if inflammation is mild, if mechanical pain is the major problem. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. Hydroxychloroquine dose for rheumatoid arthritis Hydroxychloroquine Plaquenil Side Effects & Dosage for., Hydroxychloroquine - Alberta Rheumatology Hydroxychloroquine and citrusPlaquenil cause insomniaPlaquenil and borderline personality disorderChemical synthesis of chloroquineDelayed side effects plaquenil For the treatment of RA, hydroxychloroquine is typically taken by mouth once daily at 200-400 mg, although it can be taken at a higher dose. A loading dose of 1,200 mg daily, given for 6 weeks may decrease the time to clinical response. However, experts debate that this higher dosage may increase the risk of toxicity. Treatments for Rheumatoid Arthritis. Rheumatoid Arthritis Treatment Options Johns Hopkins.. Hydroxychloroquine User Reviews for Rheumatoid Arthritis.. The recommended hydroxychloroquine dosage for rheumatoid arthritis is 400 mg to 600 mg a day by mouth as a single dose or divided into two separate doses. However, once a good response is being maintained with hydroxychloroquine, doses may be reduced to 200 mg to 400 mg per day for maintenance. Plaquenil hydroxychloroquine "Hi, I was taking the generic form of plaquenil for over 10 years for rheumatoid arthritis. It took a few weeks to see it work but what a change for the better. Less painful joints and fatigue. Hydroxychloroquine is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine may also be used for purposes not listed in this.