I've been on plaquenil for 6 months for suspected Sjogren's syndrome (I don't have antibodies for Sjorgren's or Lupus but I do have Hashimoto's and have all the symptoms for Sjorgren's so the rheumatologist suggested a trial of plaquenil). Basically I've been on the drug since January and saw the rheumatologist on Wednesday to see how things are going. Hydroxychloroquine scleroderma Plaquenil retinopathy symptoms Chloroquine overdose fatal Return of symptoms. This would be quite variable and it may take days, weeks or months before any relapse occurs. A lot depends on the type and intensity of your original disorder. Did your ANA level fall when you were started on plaquenil? Relapse would most likely consist of return of your original symptoms. Withdrawal syndrome is found among people who take Plaquenil, especially for people who are female, 50-59 old also take medication Lyrica, and have Fibromyalgia. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food and Drug Administration FDA, and is updated regularly. Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. I do think it's helped with fatigue and muscle pain but it's hard for me to compare to Xmas as when the improvement is so gradual I think it's really hard to notice on a gradual basis. I *think* I'm improving but it's been a gradual process and I said to him that it's quite hard to tell how much of an improvement I'm feeling. Stopped plaquenil now symptoms have returned Stopping plaquenil. DailyStrength, Will you have Withdrawal syndrome with Plaquenil - eHealthMe How do you stop taking plaquenilWithdrawal effects of plaquenil Jan 29, 2007 I don't agree with her. of couse some of these symptoms do come with Plaquenil, but the nausea and bad reflux I have had for a very long time BEFORE the Plaquenil. She has given me an oral tablet to take for the itch, steroid cream for the rash, and she was going to give me something to empty my stomach out quicker but we both forgot before my session was finished. Coming Off Plaquenil questions - Sclero Forums MAIN.. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Rheum had me stop plaquenil on it for +Ana, symptoms to see.. Your symptoms may begin to improve within one or two months of starting Plaquenil; however, some people do not show signs of improving until they have been taking Plaquenil for six months. Do not smoke while taking Plaquenil. Smoking can reduce the benefits Plaquenil provides. Always follow your doctor’s instructions exactly when taking Plaquenil. Hi, Has anyone had any problems with adverse effects from Plaquenil? I take 200 mg twice per day for 2 1/2 months now. At first, I had GI upset which resolved, but for that past month, I have had blurry vision, severe headaches, weakness, ringing ears and dizziness. I quit taking it Sunday and called my rheumatologist Nov 12, 2009 Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up.