Part of that is due to less exercise, part due to having no appetite thus feeling like anything I can get down is ok. Well, now I've been exercising at almost my pre-Lupus rate (ran a marathon a year before), eating a more moderate diet (clean protein, vegs & fruits), and am no longer taking that weight & bloat causing Prednisone (off Pred almost 2 yrs now). My question: Do you feel like you've gained weight on Plaquenil (ie without Prednisone)? Nursing interventions for hydroxychloroquine Plaquenil time to work I have been on plaquenil for many a year, and it has not affected my weight at all. If you go to or rxlist.com, neither of them list weight gain as a side effect, while they both list "nausea, vomiting, stomach pain; loss of appetite, weight loss" as side effects. Irreversible retinal damage observed in some patients who had received hydroxychloroquine sulfate; significant risk factors for retinal damage include daily doses of hydroxychloroquine sulfate greater than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than five years, subnormal glomerular filtration. How to use Plaquenil. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage is also based on weight. My Lupus has been really quiet for about 2 yrs, and I'm afraid to change anything. The Plaquenil drug side effects list weight loss, but some people have reported weight gain instead. My rheumy wants me to come down and then off my Plaquenil, but I've been resisting simply because I'm afraid to. Plaquenil dosage according to weight Plaquenil Risk Calculators, Plaquenil hydroxychloroquine sulfate dosing, indications. Bull's eye maculopathy hydroxychloroquine The usual hydroxychloroquine dose that is prescribed is 400 mg/day. For this dosage, any woman with an ideal body weight less than 135 pounds would be in the toxic dose range. As one can see, the height that corresponds to an ideal body weight of 135 pounds varies across the formulas. Ideal Body Weight for Calculating Hydroxychloroquine Dosage.. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Rx Side Effects New Plaquenil Guidelines and More - American.. The most recent 2016 guidelines from the American Academy of Ophthalmology AAO recommend the dose of HCQ ≤5 mg/kg real body weight to minimize toxicity 1. According to these new guidelines, the risk of HCQ retinal toxicity is less than 1 % in the first year of therapy and less than 2 % up to 10 years of therapy. Approximately 23% of the treated patients showed abnormal weight gain P = 0.001. Patients treated with doxycycline and hydroxychloroquine presented significantly lower concentrations of Bacteroidetes P = 0.002, Firmicutes P = 0.01, and Lactobacillus P = 0.02. Dosage is based on body weight. The typical starting dose is 13 mg/kg maximum dose 800 mg.