It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. What does plaquenil used for Plaquenil and chronic fatigue Systemic lupus erythematosus SLE patients using hydroxychloroquine have a markedly lower risk of a type of abnormal heart rhythm called atrial fibrillation than those not being treated with the therapy, according to a retrospective study. Antimalarial therapy such as hydroxychloroquine in systemic lupus erythematosus SLE has documented benefit for reducing disease activity, improving survival, and reducing the risk of SLE-related thrombosis and myocardial infarction. In patients with systemic lupus erythematosus SLE, hydroxychloroquine prevents disease flares and damage accrual and facilitates the response to mycophenolate mofetil in those with renal involvement. A study was undertaken to determine whether hydroxychloroquine also exerts a protective effect on survival. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Hydroxychloroquine and sle Systemic Lupus Erythematosus SLE CDC, Hydroxychloroquine in systemic lupus erythematosus SLE Chloroquine inhibits Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. Treating Lupus with Anti-Malarial Drugs Johns Hopkins.. Effect of hydroxychloroquine on the survival of patients.. Is Hydroxychloroquine Helpful for Patients with.. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Hydroxychloroquine, an antimalarial drug, is traditionally used in the treatment of SLE. Its effectiveness in treating APS has been previously questioned. In vitro and in vivo studies showed a beneficial effect of hydroxychloroquine on thrombosis 121–124. Jan 14, 2019 A Systemic lupus erythematosus, SLE is disease in which immune system is over-active causing inflammation in joints skin or any organ system. There are many areas where better approaches in SLE could improve outcomes. One example relates to hydroxychloroquine HCQ key drug which can reduce risk of serious disease flares.