Mechanism of chloroquine resistance

Discussion in 'Canadian Pharmacies' started by JackDAripper, 25-Feb-2020.

  1. snegir User

    Mechanism of chloroquine resistance


    Resistance to currently available antimalarial drugs has been confirmed in only two of the four human malaria parasite species, first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

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    The clinical usefulness of chloroquine, and in some recent cases of quinine as well, has been much reduced by the evolution and spread of chloroquine resistant malaria parasites. The mechanism of resistance involves a reduced accumulation of the drug, although again the mechanism involved is controversial. The spread of chloroquine resistance poses a serious challenge to find strategies to treat malaria. an understanding of the molecular mechanisms involved in chloroquine resistance can lead to. ChloroquineResistance In Plasmodium Falciparum. With cholorquine there is emergence of resistance, which has limited its use. Primarily highly effective against febrile illness, relief is quickly achieved within 24 hours. It is easily available, well tolerated and cost effective but now uses are declining because of resistance. 1.

    Although resistance to these drugs tends to be much less widespread geographically, in some areas of the world, the impact of multi-drug resistant malaria can be extensive. Has also developed resistance to nearly all of the other currently available antimalarial drugs, such as sulfadoxine/pyrimethamine, mefloquine, halofantrine, and quinine.

    Mechanism of chloroquine resistance

    Chloroquine C18H26ClN3 - PubChem, Molecular mechanisms involved in chloroquine resistance.

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  6. Resistance to chloroquine has, however, steadily spread since the 1960s from two foci, one in South America and one in South East Asia. Throughout the 1980s, chloroquine resistance spread through Africa, the global heartland of malaria mortality and morbidity, and there are very few effective and affordable drugs to take its place.

    • Malaria Dissecting chloroquine resistance Current Biology.
    • Chloroquine – howMed.
    • On the Mechanism of Chloroquine Resistance in Plasmodium falciparum.

    Chloroquine-resistant Plasmodium falciparum accumulate significantly less chloroquine than susceptible parasites, and this is thought to be the basis of their resistance. However, the reason for the lower accumulation of chloroquine was unknown. The resistant parasite has now been found to release chloroquine 40 to 50 times more rapidly than the susceptible parasite, although their initial. Resistance to currently available antimalarial drugs has been confirmed in only two of the four human malaria parasite species, Plasmodium falciparum and P. vivax. It is unknown if P. malariae or P. ovale has developed resistance to any antimalarial drugs. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

     
  7. Cinzento Well-Known Member

    Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Chloroquine has tumor-inhibitory and tumor-promoting effects. Stage-specific Activity of Potential Antimalarial Compounds. COVID-19
     
  8. Geralt Guest

    Malaria infection in pregnant women is associated with high risks of both maternal and perinatal morbidity and mortality. Chloroquine - Uses, Dosage, Side Effects, Composition & more Practo Methotrexate and Pregnancy Is It Safe If You Have RA? Chloroquine Aralen - Side Effects, Dosage, Interactions.
     
  9. mdss XenForo Moderator

    Comparison of hydroxychloroquine and chloroquine use and the. Comparison of hydroxychloroquine and chloroquine use and the development of retinal toxicity. Finbloom DS, Silver K, Newsome DA, Gunkel R. We assessed the frequency of retinal toxicity in patients receiving either chloroquine or hydroxychloroquine and factors which may predict patient susceptibility to toxicity.

    Chloroquine Aralen - Side Effects, Dosage, Interactions.