Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data. Plasmodium falciparum chloroquine resistance Hydroxychloroquine and lansoprazole Plaquenil prescription assistance programs How to switch from plaquenil to methotrexate Plaquenil Guidelines Point Out New Risks, New Presentation Written By Jean Shaw, Senior Editor, interviewing Rebekah A. Braslow, MD, Sang Jin Kim, MD, and Michael F. Marmor, MD Add to My To-Do List Summary Breast cancer is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years, also take medication Enbrel, and have High blood pressure. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking Plaquenil and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Please check with the appropriate physician regarding health questions and concerns. The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Plaquenil and cancer risk Hydroxychloroquine - Memorial Sloan Kettering Cancer Center, Will you have Breast cancer with Plaquenil - eHealthMe Doses of hydroxychloroquineCan plaquenil help skin cancerPlaquenil retionpathy According to Drugs.com, Plaquenil given for a long term can cause retinal disorders after a few months or years of daily use--especially if the dose exceeds 400mg per day. The risk of retinal damage increases at doses of 600mg to 700mg. Long-Term Side Effects of Plaquenil for Rheumatoid.. Plaquenil Uses, Dosage & Side Effects -. Lupus and Cancer Johns Hopkins Lupus Center. Aug 02, 2010 Yes, Plaquenil suppresses the immune system. Autoimmune disease such as Sjogrens occurs when the body gets "confused" and attacks healthy tissue instead of just attacking the germs. Basically, the immune system is a bit out of control. Plaquenil works by suppressing the immune system. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. On the other hand, the risk of metastasis was significantly lower during the time of exposure. Also, hydroxychloroquine and chloroquine significantly decreased the risk of death, both in the overall population and in those diagnosed with incident cancer during follow-up.