Chloroquine phosphate mechanism of action

Discussion in 'Chloroquin' started by viR, 23-Feb-2020.

  1. DriverCat New Member

    Chloroquine phosphate mechanism of action


    Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems.

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    Chloroquine phosphate is a 4-aminoquinolone that acts by inhibiting heme polymerase. 198 Chloroquine is well tolerated and in appropriate doses may be safely used by young children and pregnant women. 199 Transient nausea or vomiting is seen in a small proportion of individuals and may usually be reduced by taking the drug with food. It is a prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses. PubChemThe mechanism of plasmodicidal action of chloroquine is not completely certain. Mechanism of Action. Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. However, the mechanism of plasmodicidal action of chloroquine is not completely certain. Activity in vitro and in vivo

    For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor.

    Chloroquine phosphate mechanism of action

    Action of chloroquine phosphate in rheumatoid arthritis. II., Chloroquine C18H26ClN3 - PubChem

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  5. Mechanism of action of Chloroquine It interferes with the metabolism and hemoglobin utilization by the parasites by binding to and inhibiting the DNA and RNA polymerase. It also concentrates within the parasite vesicles and interferes with the acid-base balance of the parasite inhibiting the growth of the parasite.

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    Chloroquine phosphate is a 4-aminoquinoline compound for oral administration. Chloroquine is an antimalarial and amoebicidal drug. The drug possesses antimalarial actions and exerts a beneficial effect in lupus erythematosus chronic discoid or systemic and acute or chronic rheumatoid arthritis. The precise mechanism of action is not known. The sulfate and phosphate salts of chloroquine have both been commercialised as antimalarial drugs. Hydroxychloroquine has also been used as an antimalarial, but in addition is now broadly used in autoimmune diseases such as lupus and rheumatoid arthritis. Chloroquine binds to heme or FP to form the FP-chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products.

     
  6. brazilius XenForo Moderator

    Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Hydroxychloroquine Oral Uses, Side Effects, Interactions. Is the medication hydroxychloroquine a controlled substance? Hydroxychloroquine - Side Effects, Dosage, Interactions.
     
  7. rolker Guest

    Mucolipidosis type IV (MLIV) is caused by mutations in the ion channel mucolipin 1 (TRP-ML1). Chloroquine analogues in drug discovery new directions of. Chloroquine - an overview ScienceDirect Topics Inhibition of Endosomal/Lysosomal Degradation Increases the.
     
  8. usaoffer New Member

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