Patients starting chloroquine (CQ) or hydroxychloroquine (HCQ; i.e. Plaquenil) should have a baseline examination that serves as a reference point, as well as to rule out any preexisting maculopathies. Chloroquine autophagy inhibitor lc3 Hydroxychloroquine in chikungunya Plaquenil and sun Plaquenil eye exam report Currently, one of the primary functional screening tests recommended for the evaluation of Plaquenil retinal toxicity is 10-2 white stimulus automated visual fields; however, research shows Asian patients benefited from 24-2 or 30-2 visual fields, given that toxicity often manifests changes beyond the macula in these patients. 9 Because spectral-domain optical coherence tomography SD-OCT is readily accessible and able to detect early structural damage prior to clinical funduscopic findings. Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. However, risk increases with duration of use. Review of Optometry CE, March 2020 Optometric Study Center Courses published monthly in Review of Optometry and Review of Cornea & Contact Lenses, offering either 1 or 2 hours of CE credit. Processing fees apply. Exam valid for credit up to three years from release date. The American Academy of Ophthalmology released an updated set of screening recommendations for hydroxychloroquine (Plaquenil) and chloroquine to account for the many studies that have shown the effects of these medications on the retina (1). While most rheumatologists are now routinely prescribing their patients 400 mg of HCQ (or 250 mg CQ) daily for the management of conditions like systemic lupus erythematosus and rheumatoid arthritis, individuals of short stature often have their dosage determined off of their ideal body weight to avoid overdosing. Plaquenil testing review of optometry Hydroxchloroquine and Chloroquine Toxicity - Eye Lessons, Rx Side Effects New Plaquenil Guidelines and More. Best alternative to plaquenil for lupusChloroquine toxicity Aug 30, 2011 She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to presentation. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Review Education Group Review's Continuing Education. Plaquenil Retinotoxicity - Eye Lessons. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a ppatient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. Newer guidelines state that daily dose 5mg/kg of real weight/day can lead to toxicity. Retinal toxicity is irreversible and can progress after cessation of hydroxychloroquine, thus early screening is important to limit potential vision loss. Baseline screening and annual screening after five years is recommended. Generally, the plaquenil eye exam is something everyone here has done. These are the patients where you need to knock out that extra 10-2 in your exam.except that may not be true anymore. What is plaquenil used for? HCQ is used for RA, Lupus and for SS among other conditions. RA is the most common of these at ~1% of the population.