One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Plaquenil plm Marine chloroquine phosphate With Plaquenil related toxicity, the pigment in the macula can change and alter vision by producing blurring and distortion of objects. These changes, if they are going to occur, happen slowly over a long period of time. Your eye care provider can examine the macula and detect subtle changes before you begin to notice any symptoms of problems. Hydroxychloroquine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away headache; dizziness; loss of appetite; nausea; diarrhea; stomach pain; vomiting; skin rash; If you experience any of the following symptoms, call your doctor immediately Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Symptoms of eye side effects from plaquenil Hydroxychloroquine Plaquenil Toxicity and Recommendations., Hydroxychloroquine MedlinePlus Drug Information Plaquenil lupus en espanolPlaquenil and erectile dysfunctionChloroquine phosphate 250 mg base Taking Hydroxychloroquine develop toxicity2 It’s rare for side effects to occur with Plaquenil if the medication is dosed properly Side effects Blurred vision, bull’s eye maculopathy, scotoma, vortex keratopathy, headache, accommodative dysfunction, whitening of eyelashes, phototoxicity3 Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Plaquenil Side Effects Common, Severe, Long Term -. Inability to move the eyes. increased blinking or spasms of the eyelid. joint or muscle pain. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, and sex organs. loss of hearing. lower back or side pain. noisy breathing. painful or difficult urination. red irritated eyes. red skin lesions, often with a purple center If common side effects do occur, they are usually minor and last only for a short period of time. Please note the rare side effects listed below, specifically retinopathy, which causes damage to the eyes. Side effects associated with Plaquenil are placed in three categories common. MORE COMMON side-effects include Nausea & diarrhea – Plaquenil agrees with most people. Rarely it can cause an upset stomach or diarrhea. Skin rash – Plaquenil can rarely cause a rash. Patients who experience this rare side effect should stop taking this medicine and contact their doctor. Headaches – Plaquenil can rarely cause a headache.