It has been shown in multiple SLE populations to associate with improved survival (1-3) and specifically has been found to be effective in the treatment of cutaneous disease(4), arthritis(5), with an augmenting effect on the efficacy of mycophenolate mofetil in the management of nephritis(6) amongst other positive health effects(7, 8). Füzéry AK, Breaud AR, Emezienna N, Schools S, Clarke WA. Hydroxychloroquine is a safe, non-immunosuppressive therapy with good tolerability. A rapid and reliable method for the quantitation of hydroxychloroquine in serum using turbulent flow liquid chromatography-tandem mass spectrometry. Hydroxychloroquine protects against viruses Hydroxychloroquine and sle Plaquenil method of action Mg 310 mg base PO once every 7 days. Alternatively, 6.5 mg/kg/dose 5 mg base/kg/dose; Max 400 mg/dose or 310 mg base/dose. Dosing should begin 2 weeks before entering and continue for 4 weeks after leaving the endemic area. The CDC suggests hydroxychloroquine as an alternative to chloroquine. PLAQUENIL hydroxychloroquine sulfate tablets is indicated for the treatment of rheumatoid arthritis, and discoid and systemic lupus erythematosus, in patients who have not responded satisfactorily to drugs with less potential for serious side effects. Glucose-6-phosphate dehydrogenase G6PD deficiency is associated with hemolysis and renal impairment; use with caution Dermatologic reactions to hydroxychloroquine may occur Patients are prone to. There is also significant controversy surrounding how to best dose this medication, with some advocating dosing based on actual body weight (capped at 400 mg per day), whilst others are in favor of calculating the daily dose based on ideal body weight. Adherence to treatment in systemic lupus erythematosus patients. However, there are increasing concerns about retinopathy, in particular, in light of new screening methods, which are thought to have increased sensitivity(9). Costedoat-Chalumeau N, Pouchot J, Guettrot-Imbert G, Le Guern V, Leroux G, Marra D, et al. Hydroxychloroquine hemodialysis UpToDate, Plaquenil Hydroxychloroquine Sulfate Hydroxychloroquine sulfate for lupus time usagePlaquenil use in patientsSaliva drug test hydroxychloroquinePlaquenil use for lupus Objectives To determine dosing patterns and examine predictors of filled hydroxychloroquine HCQ prescriptions in patients with systemic lupus erythematosus SLE with end-stage renal disease ESRD. Methods This was a retrospective cohort study of patients with SLE in the US Renal Data System USRDS database in fiscal year 2011. Hydroxychloroquine in patients with systemic lupus.. Plaquenil hydroxychloroquine sulfate dosing, indications.. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Hydroxychloroquine is generally considered to be the safest DMARD, and a “go to” drug for pregnancy. Retinal pigment changes and retinal toxicity can occur with prolonged use. Early changes tend to be reversible but may progress despite discontinuation if advanced. Mar 14, 2016 Hydroxychloroquine blood levels can be quantified by high performance liquid chromatography 11, which is a widely available means of measuring drug concentrations. It is also possible to measure serum levels but for reasons of pharmacokinetic stability and reliability. Hydroxychloroquine keratopathy is caused by deposition of unmodified hydroxychloroquine salts within the epithelium. Pathophysiology. Hydroxychloroquine binds to melanin, accumulates in the RPE, and remains there for long periods of time. It is directly toxic to the RPE, causing cellular damage and atrophy.