It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Taking plaquenil and sun exposure Hydroxychloroquine retinopathy pathogenesis Hydroxychloroquine oral tablet doesn’t cause drowsiness, but it can cause other side effects. More common side effects. The more common side effects that can occur with hydroxychloroquine include Skin Hyperpigmentation with Hydroxychloroquine Hydroxychloroquine Plaquenil is a common trade name is an anti-inflammatory oral medication that is commonly used to treat many autoimmune diseases. In the hair clinic, we use it for diseases such as lichen planopilaris, frontal fibrosing alopecia, pseudopelade and discoid lupus. Blistering, peeling, loosening of the skin blurred vision or other vision changes chest discomfort, pain, or tightness cough or hoarseness dark urine decreased urination defective color vision diarrhea difficulty breathing difficulty seeing at night dizziness or fainting fast, pounding, uneven heartbeat For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Hydroxychloroquine skin darkening Hydroxychloroquine Skin Support, Skin Pigmentation with Hydroxychloroquine Plaquenil. Acriflavine and chloroquineWart plaquenil Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. PATIENT FACT SHEET Hydroxychloroquine Plaquenil. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Skin Discoloration and Plaquenil - Arthritis Information. Indigestion, diarrhoea, headache, blurred vision, darkening of the skin, or bleaching of the hair. Hydroxychloroquine can aggravate pre-existing psoriasis. Does hydroxychloroquine affect fertility or pregnancy? Hydroxychloroquine must be avoided during pregnancy as it may harm the unborn child. About 25% of patients receiving chloroquine or hydroxychloroquine for several years develop bluish-grey pigmentation on face, neck and sometimes lower legs and forearms Continuous long-term use may lead to blue-black patches, especially in sun-exposed areas Objective To describe the clinical features and outcome of hydroxychloroquine HCQ-induced pigmentation in patients with systemic lupus erythematosus SLE. Design, Setting, and Participants In a case-control study conducted at a French referral center for SLE and antiphospholipid syndrome, 24 patients with SLE.