Mom has Lupus like me, but she was diagnosed when she was 40 yrs old and now she is 58. She has and enlarged heart, diabetes, had a stroke, and failing kidneys. Lupus and plaquenil problems Does hydroxychloroquine always help when taking methotrexate Chloroquine phosphate puffer fish Plaquenil and vascular system Plaquenil hydroxychloroquine and prednisone are used to treat symptoms of rheumatoid arthritis. Plaquenil is also used to treat or prevent malaria, and to treat symptoms of discoid or systemic lupus erythematosus. Prednisone is also used to treat or manage many conditions. Yes, anti-malarials can be taken with other lupus medications, including corticosteroids e.g. prednisone, immunosuppressives, cytotoxic drugs, and NSAIDs. Anti-malarial drugs may be given in combination with prednisone to reduce the amount of steroid needed to control lupus symptoms and thus to alleviate some of the side effects of the steroid. I understand this drug is very effective in preventing organ damage and my doctors made me aware of this. I am still a Prednisone refuser. I take Plaquenil, Endep, Pariet, Tramadol and Celebrex to stabilise my Lupus and give pain relief and Atenolol for my heart. I see my rheumatologist every 3 to 4 months and my GP in between times. Plaquenil is an anti-malarial that slows the progression of the disease. This is a very popular and normal combination, I'd say that at least 75% of the lupus forum members have been on it! Prednisone and plaquenil lupus Prednisone and Plaquenil drug interaction Lupus nephritis., Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus Center Plaquenil testing Prednisone Side Effects Adrenal insufficiency Adrenal gland a gland on top of the kidney It makes prednisone-like steroids These are very important for living Makes more steroids during times of stress and infection Regular prednisone use causes the gland to stop making its own steroids Systemic Lupus Erythematosus Living With Lupus. Prednisone for Lupus DailyStrength. Prednisone and Plaquenil question" Lupus Community.. Prednisone is the most commonly prescribed steroid for lupus. Prednisolone and methylprednisolone Medrol® are similar to prednisone. Some physicians prefer to prescribe these if you have liver problems. Most people take steroids in pill form. But, creams or gels applied to the skin are often used for cutaneous skin lupus. The Benlysta made me vomit, the steroids, well, we all know how bad they are, and I’ve been on plaquenil seemingly forever. I finally stopped the Benlysta treatments. I want to decrease my intake of prednisone, but I don’t know how I’d function without it. But, the weight gain alone has been depressing. My boyfriend was diagnosed with lupus about a year ago. Initially he was prescribed 50 mg of prednisone cause his body was aching so bad. He’s trying to taper off of it, but something will start aching really bad. He was on plaquenil, but he started having breathing problems.