Chloroquine toxicity eye

Discussion in 'Discount Prescriptions' started by evgeny_kras, 03-Mar-2020.

  1. Mypaku Moderator

    Chloroquine toxicity eye


    Although their therapeutic and toxic doses differ, they are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity. The image below depicts hydroxychloroquine retinopathy. Fluorescein angiogram of left macula in patient with hydroxychloroquine retinopathy.

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    Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs. One of the most significant side effects of the drug is its possibility of causing eye problems resulting in blurred or decreased vision. The most common issue is damage to the retina. It can impair your color vision or damage the retinal cells particularly in the area right around the central vision. VF testing in a patient with hydroxychloroquine toxicity demonstrates parafoveal depression, more prominent in the left than the right eye. These changes remained stable upon cessation of the medication.

    Retinopathy may be asymptomatic or may cause central or paracentral scotomas leading to difficulty reading or performing fine visual tasks (due to parafoveal metamorphopsia). Reprinted from American Journal of Ophthalmology, Vol 104, Johnson and Vine, Hydroxychloroquine therapy in massive total doses without retinal toxicity, pages 139-144, Copyright 1987, with permission from Elsevier Science.

    Chloroquine toxicity eye

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  7. Hydroxychloroquine can cause irreversible retinal toxicity, resulting in bilateral bull’s eye retinopathy, but is regarded as less toxic to the retina than chloroquine and it does not cause the corneal deposits seen with chloroquine therapy.

    • Hydroxychloroquine DermNet NZ.
    • Retina Today - Imaging in Hydroxychloroquine Toxicity April 2019.
    • Hydroxychloroquine toxicity - EyeWiki.

    Compared with focal ERG, mfERG is more appropriate for the evaluation of chloroquine and/or hydroxychloroquine toxicity because it generates local ERG responses topographically across the posterior pole and can document a parafoveal or extramacular depression in early retinopathy or bull's eye distribution of ERG depression in late stages. Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. The usefulness of hypokalemia as an indicator in the evaluation of chloroquine toxicity was studied in a retrospective series of 191 acute chloroquine poisonings. Results indicated that the risk of severe poisoning and death are proportional to the degree of hypokalemia.

     
  8. p_boss XenForo Moderator

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Biaxin Clarithromycin + Flagyl Metronidazole Combo Flagyl and plaquenil - BlueTabs Plaquenil and Doxycycline hyclate drug interactions - from. - eHealthMe
     
  9. Makedonsky XenForo Moderator

    Hydroxychloroquine - Wikipedia Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda.

    Clinical Trials Using Hydroxychloroquine - National Cancer.
     
  10. WLB Well-Known Member

    Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13

    Retinal Physician - Hydroxychloroquine Maculopathy An.