Ongoing monitoring of blood counts, liver and kidney function is also required. Prescribed for Acute Lymphocytic Leukemia, Acute Lymphoblastic Leukemia, Rheumatoid Arthritis, Psoriatic Arthritis, Solid Tumors, Small Cell Lung Cancer, Systemic Sclerosis, Neoplastic Diseases, Trophoblastic Disease, Osteosarcoma, Non-Small Cell Lung Cancer, Non-Hodgkin's Lymphoma, Psoriasis, Mycosis Fungoides, Dermatomyositis, Breast Cancer, Choriocarcinoma, Meningeal Leukemia, Graft-versus-host disease, Head and Neck Cancer, Juvenile Idiopathic Arthritis, Lymphoma. Difference between hydroxychloroquine and methotrexate Reviews on plaquenil Hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. The effects of methotrexate and hydroxychloroquine combination therapy vs methotrexate monotherapy. combination treatment was preferentially given to patients with worse RA, so this would result in bias in the conservative direction. which is probably due to treatment intensification in the monotherapy group; 42% started an extra. Plaquenil is one of the firs line drugs and may or may not have side effects. MTX is more of a "chemo" medication and may or may not have side effects. I would encourage you to look at quality of life issues and go slowly if you are not in a hurry to squelch all of the discomfort of RA. " Prednisone effectively controls inflammation and an overactive immune system but may not be suitable for everybody. May also be prescribed off label for Bladder Cancer, Acute Nonlymphocytic Leukemia, Soft Tissue Sarcoma, Scleroderma, Pityriasis rubra pilaris, Pemphigus, Pemphigoid, Pancreatic Cancer, Ovarian Cancer, Mantle Cell Lymphoma, Brain Tumor, Bullous Pemphigoid, Cervical Cancer, Cogan's Syndrome, Colorectal Cancer, Ectopic Pregnancy, Eczema, Esophageal Carcinoma, Gastric Cancer, Hodgkin's Lymphoma, Uveitis. Whichhis worse plaquenil or methotrexate Compare Plaquenil vs Methotrexate -, Effects of methotrexate and hydroxychloroquine combination. Can plaquenil and metoprolol tartrateHow long does it take hydroxychloroquine to affectnyour eyea Does anyone else feel worse on Plaquenil? Support Forums Rheumatoid Arthritis. then I started taking methotrexate as well so I think it's the combo that gave me some mobility back. But I do still have swelling, and dizziness as well. I only take hAlf a pill a day so that might lessen nausea or whatever side effects. maybe Plaquenil too. Does anyone else feel worse on Plaquenil?. Methotrexate or Plaquenil? DailyStrength. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Plaquenil vs Methotrexate.sure to know the potential side affects and what monitoring needs to take place. I thought I was told that with Plaquenil you need to monitor your eyes more carefully. With both drugs you would need regular blood tests to monitor various blood counts as well as liver function. Apr 13, 2005 Methotrexate MTX, an anti-metabolite that inhibits purine pathways, has been the hallmark of standard of care for many years in the treatment of rheumatoid arthritis RA. However, many RA patients continue to have active disease despite maximal doses of methotrexate.