I can say that the prednisone wean was successful, even after having only been on plaquenil a few months. To answer some of your other questions, it was the same timeframe for me. Chloroquine treatment malaria Production of chloroquine Chloroquine 250 mg tablet Most common side effects people have besides Withdrawal syndrome * Drug Ineffective 15 people, 30.00%. Pain 12 people, 24.00%. Nausea And Vomiting 12 people, 24.00%. Feeling Abnormal 11 people, 22.00%. Insomnia sleeplessness 11 people, 22.00%. I believe it is like any other drug, side effects can and do happen, but they are very individualized. I would like to be able to keep taking plaquenil, I just want to reduce my dose by half. I had no idea it was going to so profoundly impact me, and I guess I feel like I need to understand why. As PLAQUENIL may enhance the effects of a hypoglycemic treatment, a decrease in doses of insulin or antidiabetic drugs may be required. Drugs That Prolong QT Interval And Other Arrhythmogenic Drugs. PLAQUENIL prolongs the QT interval and should not be administered with other drugs that have the potential to induce cardiac arrhythmias. But I couldn't handle the heart issue and not being able to breathe (plus all the other pains). Yesterday would've been my 4th day at the reduced dose. Plaquenil withdrawal side effects Plaquenil oral Reviews and User Ratings Effectiveness., Let me tell you what weaning down from Plaquenil is like. What is hydroxychloroquine used for Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. Plaquenil Oral Uses, Side Effects, Interactions.. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Side effects include digestive problems, skin rash and disorders of skin pigmentation. One of the most serous side effects includes disorders of eyesight. The side effects related to the eyesight are blurred vision, sensitivity of the eyes to sun light, decreased night or color vision, decreased ability to see objects at the edge of vision, black spots in the vision or light flashes or streaks. Hello all, I am currently new to this site and ran across the discussion about stopping Plaquenil. I have been taking Plaquenil for about 8-9 months and thought that it was not helping me because I still have a fair amount of joint pain, fatigue, muscle pain and so many other issues. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects.