The clinical trials on this list are studying Hydroxychloroquine. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials look at new ways to prevent, detect, or treat disease. Hydroxychloroquine side effects ocular Plaquenil 200mg dosage Huntsman Cancer Institute, University of Utah Photo National Cancer Institute Investigators at the Huntsman Cancer Institute at the University of Utah are conducting a Phase I clinical trial to study the side effects and best dose of hydroxychloroquine when given together with trametinib MEKINIST ®, Novartis in treating patients with pancreatic cancer that has spread to nearby tissue, lymph nodes, or other places in the body and cannot be removed by surgery. Patients with previously treated metastatic pancreatic cancer were administered HCQ at 400 mg n = 10 or 600 mg n = 10 twice daily. The primary endpoint was 2-month progression-free survival PFS. The team speculated that this disruption of energy production may cause pancreatic cancer cells to rely more heavily on autophagy—and therefore become more vulnerable to drugs that target it. They turned to an autophagy inhibitor called hydroxychloroquine and a drug that blocks a protein in the MAPK pathway. Talk to your doctor for help in deciding if one is right for you. You may want to think about taking part in a clinical trial. Hydroxychloroquine pancreatic cancer Chloroquine reduces hypercoagulability in pancreatic cancer., Phase II and Pharmacodynamic Study of Autophagy. - PubMed Central PMC Chloroquine diphosphate salt msdsDo chloroquine cause splenomegalyHydroxychloroquine eye screeningWhat are the side affects of hydroxychloroquineDetoxing from plaquenil Binimetinib and Hydroxychloroquine in Treating Patients With KRAS Mutant Metastatic Pancreatic Cancer The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Binimetinib and Hydroxychloroquine in Treating Patients With.. Hitting an Elusive Target in Pancreatic Cancer - National.. Trametinib and Hydroxychloroquine in Treating Patients With.. Pancreatic carcinoma is found among people who take Hydroxychloroquine sulfate, especially for people who are male, 50-59 old, have been taking the drug for 6 - 12 months, also take medication Methotrexate, Autophagy may prevent normal cells from developing into tumor cells, but it may also protect tumor cells by destroying anticancer drugs or substances taken up by them. Giving hydroxychloroquine together with binimetinib may work better in treating patients with pancreatic cancer compared to binimetinib alone. Drugs used in chemotherapy, such as hydroxychloroquine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving trametinib together with hydroxychloroquine may work better in treating patients with pancreatic cancer.