I've stopped Sulfa as I was experiencing a bad taste & smell, which may be caused by sulfa. After a while it wasn't as effective and I too was prescribed methotrexate alongside. I'm about to start MTX & am hoping that I wont have side effects with that! The side effects of the methotrexate for me were horrendous (chronic chest infections) and I'm now asthmatic as a result. Aralen patient teaching Ra hydroxychloroquine Hydroxychloroquine side efects Otis pregnancy plaquenil O'Dell J R, Leff R, Paulsen G, Haire C, Mallek J, Eckhoff P J. et al Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine or a combination of the three medications results of a two year, randomized, double‐blind, placebo‐controlled trial. Arthritis Rheum 2002 46 1164–1170.1170 Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications results of a two-year, randomized, double-blind, placebo-controlled trial. Conclusions Triple therapy methotrexate plus sulfasalazine plus hydroxychloroquine and most regimens combining biologic DMARDs with methotrexate were effective in controlling disease activity, and all were generally well tolerated in both methotrexate naive and methotrexate exposed patients. I had side effects from MTX, which largely wore off, but haven't had any problems with the Hydroxy or Sulpha. I refuse to take it now even if its my passport to biologic treatment. I started with MTX which worked, but not enough so the others were added in which has been better. Sulfasalazine hydroxychloroquine and methotrexate Leflunomide, Sulfasalazine and Hydroxychloroquine for Rheumatoid., Treatment of rheumatoid arthritis with methotrexate and. Plaquenil product monograph canada Hydroxychloroquine plaquenil and sulfasalazine azulfidine are used for mild rheumatoid arthritis. they are not as powerful as other disease-modifying antirheumatic drugs, but they usually cause fe What are the side effects of hydroxychloroquine and sulfasalazine in.. Methotrexate monotherapy and methotrexate combination.. Methotrexate vs Sulfasalazine Comparison -. Sulfasalazine is also a potent inhibitor of the activation of the transcription factor NF-κB. Like methotrexate, sulfasalazine has inhibitory effects on AICAR transformylase and, as such, promotes the accumulation of adenosine and its anti-inflammatory actions via the adenosine A 2A receptor. Methotrexate in combination with sulfasalazine is more effective in rheumatoid arthritis patients who failed sulfasalazine than in patients naïve to both drugs. Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Traditional DMARDs Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies Amy C. Cannella, James R. O’dell Key Points Methotrexate is one of the most durable and frequently used disease-modifying antirheumatic drugs DMARDs in monotherapy as well as the cornerstone of combination therapy for rheumatoid arthritis RA.