Take this medicine with meals or milk to lessen stomach upset, unless otherwise directed by your doctor. Your infection may not clear up if you stop using the medicine too soon. Plaquenil pulmonary fibrosis Plaquenil drug action Hydroxychloroquine and live vaccines Uses for plaquenil Nov 25, 2019 Dose adjustment The dose may need to be reduced temporarily if adverse side effects occur; after 5 to 10 days the dose may gradually be increased to the optimum response level. Maintenance dose 200 to 400 mg 155 mg to 310 mg base orally daily. Comments -This drug should be taken with a meal or a glass of milk. Nov 11, 2008 The symptoms that you experienced on increasing the Plaquenil might be due to the same effects. The maximum recommended dose for Plaquenil is 3mgs per lb of ideal body weight. At higher doses the risk of eye damage increases long term especially if there is kidney or liver involvement. The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. The dose of this medicine will be different for different patients. For patients taking hydroxychloroquine to prevent malaria: If you are also taking kaolin or antacids, take them at least 4 hours before or after using hydroxychloroquine. Increasing plaquenil dose Plaquenil hydroxychloroquine sulfate dose, indications., Increasing plaquenil, having problems Cyclophosphamide and hydroxychloroquine side effectsHydroxychloroquine retinopathy aaoReceptor tyrosine kinase dengue virus chloroquineVd chloroquine Adult dosing ranges from 200 mg or 400 mg per day 6.5mg/kg. In some cases, higher doses can be used. It is recommended one tablet twice daily if taking more than one tablet. It is recommended to be taken with food. Hydroxychloroquine Plaquenil. Taking Plaquenil for Rheumatoid Arthritis. New Guidelines on Hydroxychloroquine Dosage - Where Are We.. Typical starting dose is 800 mg. This is followed by 400 mg three times 6 hours after the first dose, 24 hours after the first dose, and 48 hours after the first dose. Following a single 200 mg oral dose of PLAQUENIL to healthy males, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 days. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a ppatient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity.