Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Plaquenil heart rate Plaquenil and creatinine Hydroxychloroquine sul tabs 200 mg Hydroxychloroquine lupus erythematosus The finding of corneal verticillata bares no correlation with retinal toxicity and is not an indication to stop the medication. The hallmark of hydroxychloroquine toxicity is bilateral pigmentary retinopathy 1. Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is relatively rare, estimated at 1 percent after five years and rising with continued therapy. 3 However. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil corneal verticillata Retinal Screening for Hydroxychloroquine Plaquenil Toxicity., Multimodal Imaging in Plaquenil Toxicity Plaquenil weight loss reviewsChloroquine phosphate injection spcHydroxychloroquine and yellow sweat stains Cornea verticillata, also called vortex keratopathy or whorl keratopathy, is a condition characterised by corneal deposits at the level of the basal epithelium forming a faint golden-brown whorl pattern. It is seen in Fabry disease or in case of prolonged amiodarone intake. Causes Amiodarone Fabry’s disease Chloroquine Hydroxychloroquine Indomethacin Phenothiazines etc. Cornea verticillata - Wikipedia. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Chloroquine And Hydroxychloroquine Toxicity - StatPearls.. The signature ocular manifestation is the whorl-like corneal pattern of lipid glycosphingolipid deposits which are present in both hemizygous males and heterozygous females. These are sometimes referred to as cornea verticillata or Fleischer vortex dystrophy with a pattern similar to that seen in some patients using atabrine or amiodarone. Plaquenil side effects start off by effecting the surface of the eye the cornea leading to verticillata. Verticillata are deposits of salts within the corneal epithelium. This does not cause any symptoms to the patient and is reversible when the medication is stopped. Ocular side effects of amiodarone include corneal verticillata or whorl-like keratopathy, which occur in 70% to 100% of patients. This keratopathy is related to the dose and duration of treatment, generally appears after at least one month of therapy and will resolve upon discontinuation of the medication.