It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. What is hydroxychloroquine sulfate used to treat Interactions with plaquenil and leflunomide Hi Chris, welcome to this forum. Of course it is hard to say what the cause is of the increase of symptoms. But I remember I was also feeling a bit worse in the first weeks after I had started taking clarithromycin and hydroxychloroquine. Hydroxychloroquine Plaquenil Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Individuals with neurologic Lyme disease, cardiac Lyme disease, or Lyme arthritis that hasn’t responded well to oral antibiotic treatment will often be given intravenous ceftriaxone. Ceftriaxone has excellent penetration of the blood-brain barrier and is one of the most effective drugs for Lyme disease. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Plaquenil for bartonella How effective is Plaquenil for Lyme disease by duration., Hydroxychloroquine Plaquenil What is the drug hydroxychloroquine used forPlaquenil hydroxychloroquine ocdPlaquenil bowel problems He received a short course of antibiotics at that time. When I saw him initially he complained of knee pain and swelling, fatigue, generalized arthralgia joint pain, numbness and tingling and an irregular heart beat. He was seropositive by Western Blot. He was treated with Amoxil, Biaxin and Plaquenil. LymeMD Plaquenil alone?. Treatment Options Lyme Disease. A Lyme Disease Antibiotic Guide - Treat Lyme. I just started Plaquenil about. a week ago in place of tindamax as a cyst-buster, and I'm crossing my fingers that even though it's so soon that's part of what's got me finally feeling better. But I'm a little confused. My sister is on Plaquenil for undifferientated connective tissue disorder - which is just a fancy name for "sort of lupus, sort of RA, some kind of atypical autoimmune. L have been taking plaquenil for 7 years now, at first it really helped me, l never had any side effect and l went into remission for 5 1/2 years with no pain, but unfortunately the pain started to come back last year, my RA doctor added methotrexate with my plaquenil and its been 8 months now and l haven't had any improvement in fact it is. She didn't even prescribe the biaxin or plaquenil. but I had both of them prescribed to me by different doctors so I'm starting this on my own. My background is in nursing so I know enough not to do anything too stupid, and I did send the doctor a fax w/ info from these support posts that people are doing this for Bartonella, but neither I.