People who have this virus and take certain disease-modifying medications for MS may be at risk for a rare, yet serious, disease. The disease is called progressive multifocal leukoencephalopathy (PML). Where is chloroquine resistant malaria Chloroquine side effect Teva hydroxychloroquine Ra drug plaquenil The case involves a 62-year-old white female with SLE who died of progressive multifocal leukoencephalopathy caused by JC virus within the central nervous system. She was on hydroxychloroquine Plaquenil for SLE for 8 years. The JC virus, or John Cunningham virus, is a common germ. More than half of all adults have been exposed to it. It doesn't cause problems for most people, but it can be dangerous if you have a. JC virus infection resulting in Progressive Multifocal Leukoencephalopathy PML and death can occur in rituximab-treated patients with hematologic malignancies or with autoimmune diseases. Consider the diagnosis of PML in any patient presenting with new-onset neurologic manifestations. In MS, it is the loss of myelin that damages nerve function. It results when JC virus infects oligodendrocytes, cells that insulate nerve cells with myelin. Jc virus and plaquenil JC Virus Symptoms, Diagnosis and Treatment - Symptoma, JC Virus What You Need to Know About This Brain Infection Plaquenil toxicity optosWhat type of vision problems does plaquenil cause Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil Uses, Dosage & Side Effects -. Rituxan Disease Interactions -. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. Nov. 16, 2004 -- For people with rheumatoid arthritis, methotrexate is the treatment of choice in reducing pain and inflammation. But there's evidence the drug can activate a virus that can increase the risk of lymphoma and similar cancers in some patients. The study appears in this month's issue. Progressive multifocal leukoencephalopathy PML is a rare and devastating demyelinating disease of the central nervous system. The disease is caused by reactivation of a polyomavirus, the JC virus JCV, that was first described as a rare complication of chemotherapy in patients with lymphoproliferative disorders 1. Mar 16, 2016 Progressive multifocal leukoencephalopathy PML is a rare and devastating demyelinating disease of the central nervous system. The disease is caused by reactivation of a polyomavirus, the JC virus JCV, that was first described as a rare complication of chemotherapy in patients with lymphoproliferative disorders 1.