Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people. 2006;368(9529):29-3616815377Google Scholar Crossref Crandall J, Schade D, Ma Y. The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes. 2006;61(10):1075-108117077202Google Scholar Crossref Gerstein HC, Yusuf S, Bosch J. Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. 2006;368(9541):1096-110516997664Google Scholar Crossref Kitabchi AE, Temprosa M, Knowler WC. Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin. 2005;54(8):2404-241416046308Google Scholar Crossref Emami J, Pasutto FM, Mercer JR, Jamali F. Inhibition of insulin metabolism by hydroxychloroquine and its enantiomers in cytosolic fraction of liver homogenates from healthy and diabetic rats. 1999;64(5):325-33510072192Google Scholar Crossref Emami J, Gerstein HC, Pasutto FM, Jamali F. Management of plaquenil maculopathy Chloroquine adverse effects Hydroxychloroquine dangers Chloroquine proguanil malaria prophylaxis I do know that plaquenil is generally considered the least invasive drug, generally prescribed as the first line of treatment. Methotrexate is the most commonly prescribed DMARD, but it does come with the chance of side-effects. I never had any side-effects of dire consequence, but many on this forum have. Plaquenil is best taken with a meal as otherwise it may cause nausea. methotrexate is once a week usually and most of the side effects would hit the next day so some people choose to take it on a Friday or Saturday night and sleep through any potential side effects The doctor then kept me on my plaquenil and added Leflunomide Arava to replace the methotrexate. My mouth sores went away and I quit having the days of sickness from the methotrexate. There may be something better out there, but for me the Arava has made a big difference. Mode of action of chloroquine in patients with non-insulin-dependent diabetes mellitus. 1991;260(6 Pt 1): E897-E9042058666Google Scholar Quatraro A, Consoli G, Magno M. Hydroxychloroquine in decompensated, treatment-refractory noninsulin-dependent diabetes mellitus: a new job for an old drug? 1990;112(9):678-6812110430Google Scholar Crossref Arnett FC, Edworthy SM, Bloch DA. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. 1988;31(3):315-3243358796Google Scholar Crossref Krishnan E, Tugwell P, Fries JF. Insulin-sparing effect of hydroxychloroquine in diabetic rats is concentration dependent. 1999;77(2):118-12310535702Google Scholar Crossref Powrie JK, Smith GD, Shojaee-Moradie F, Sonksen PH, Jones RH. Difference between plaquenil and methotrexate Treating Rheumatoid Arthritis DMARDs vs. Biologics Everyday Health, Plaquenil vs Methotrexate rheumatoid - reddit Hydroxychloroquine anesthesiaDrug interaction of chloroquineCan hydroxychloroquine affect graves diseaseWill plaquenil show up on a drug testPlaquenil cataracts Methotrexate comes in four forms self-injectable solution, injectable IV solution, oral tablet, and oral solution. For the self-injectable solution, you can either receive it from a healthcare provider, or you or a caregiver can give it to you at home. Methotrexate self-injectable solution is used to treat psoriasis. Methotrexate Injection Side Effects, Dosage, Uses, and More. Anyone used plaquenil and arava which is better? DailyStrength. Differences Between Rheumatoid Arthritis and Lupus. I was diagnosed with RA in march and have been on increasing dose of methotrexate. Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Thanks We discussed trying methotrexate because of ongoing joint pain. She said it would be the next step after Plaquenil if my joint pain or other symptoms didn't improve. She said it was used primarily for joint and skin issues. I decided I didn't want to try it at this time but might consider it later on if necessary. I have been diagnosed with Limited Scleroderma. My choices are Methotrexate, Plaquenil or Sulfasalzine Azulfidine. I researched them and determined Plaquenil would be my last choice, although it was his first, because I already have lattice degeneration of the retina in both eyes and one of the potential side effects is retinal problems.