Pharmacokinetics of quinine chloroquine and amodiaquine

Discussion in 'Plaquenil' started by proftek, 08-Mar-2020.

  1. AD-25 XenForo Moderator

    Pharmacokinetics of quinine chloroquine and amodiaquine


    It is bioactivated hepatically to its primary metabolite, N-desethylamodiaquine, by the cytochrome p450 enzyme CYP2C8. Among amodiaquine users, several rare but serious side effects have been reported and linked to variants in the CYP2C8 alleles.

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    Alving and colleagues provided evidence of synergy in radical curative activity between primaquine and both quinine and chloroquine. Primaquine is metabolized mainly to carboxyprimaquine via monoamine oxidase and via cytochrome P450 enzymes to several other identified and unidentified metabolites that are detectable in plasma or urine. Hydroxychloroquine, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Common side effects include vomiting, headache, changes in vision and muscle weakness. Severe side effects may include allergic reactions. It does not appear to be safe during Quinine is well absorbed by mouth or following intramuscular injection even in severe cases of malaria estimated bioavailability more than 85%. Quinine and chloroquine may cause potentially lethal hypotension if given by intravenous injection.

    People who are poor metabolizers of amodiaquine display lower treatment efficacy against malaria, as well as increased toxicity. CYP2C8*1 is characterized as the wild-type allele, which shows an acceptable safety profile, while CYP2C8*2, *3 and *4 all show a range of "poor metabolizer" phenotypes.

    Pharmacokinetics of quinine chloroquine and amodiaquine

    Pharmacokinetics of antimalarials quinine and mefloquine., Hydroxychloroquine - Wikipedia

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  5. Clinical Pharmacokinetics of Zidovudine. Pharmacokinetics of Quinine, Chloroquine and Amodiaquine. Dr Sanjeev Krishna, Nicholas J. White Pages 263-299.

    • Clinical Pharmacokinetics, Volume 30, Issue 4 - Springer.
    • Pharmacokinetics of Quinine, Chloroquine and Amodiaquine..
    • Quinine Uses, Benefits & Dosage - Herbal Database.

    Pharmacokinetics of chloroquine in Thais plasma and red-cell concentrations following an intravenous infusion to healthy subjects and patients with Plasmodium vivax malaria. Br. J. Chloroquine, noncurative, and amodiaquine, partially curative, have nearly the same initial dose-independent killing with a lag phase of minimal parasite reduction at all doses between 6 and 24. The pharmacokinetics of chloroquine were studied after intramuscular and intravenous administration of the drug to healthy African adults. Chloroquine was analysed in plasma using an h.p.l.c. method and pharmacokinetic parameters were derived from the concentration-time data using a non-linear computer programme.

     
  6. White_Angel Guest

    Benefits include even better soft lens searches and helpful contact lens calculators (including RGPs and cross cylinders). Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Plaquenil vs. Aralen Prescription Treatment for Malaria. Protecting your eyesight when taking Plaquenil Lupus.
     
  7. AleM Moderator

    Rheumatoid arthritis can’t be cured, but joint pain and other symptoms can be managed. Managing patients taking DMARDs Rheumatoid arthritis, monitoring of DMARDs - BPJ 17. DMARDs Disease-Modifying Antirheumatic Drugs – CreakyJoints
     
  8. Sync New Member

    Medicines for the Prevention of Malaria While Traveling. Who should not take hydroxychloroquine? People with psoriasis should not take hydroxychloroquine. How should I take hydroxychloroquine? Both adults and children should take one dose of hydroxychloroquine per week starting at least 1 week. before traveling to the area where malaria transmission occurs. They should take one dose per week while

    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses
     
  9. nml Well-Known Member

    Treating Lupus with Anti-Malarial Drugs Johns Hopkins. What are anti-malarial drugs, and why are they used to treat lupus? Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus.

    Plaquenil and Pregnancy - Antibiotics Home Page