Sorry, there has been an issue processing your request. Alternatively, head back to the home page and see how we're leading the fight against the pain of Arthritis. Hello hope everyone is welljust a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works.i'm not expecting it to work over night but soon hopefullyi am still in so much pain everyday and hoping for some relieve soon. Plaquenil for connective tissue disease Who makes hydroxychloroquine Sorry to hear that you are having a lot of pain with your RA. I have lupus which mainly affects my joints and skin. I have been taking hydroxychloroquine which is the generic of plaquenil for the past three years. My rheumy recently added Imuran instead of methotrexate. Plaquenil hydroxychloroquine takes up to 3 months to begin working. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Does anyone know if hydroxychloroquine and methotrexate can cause weight loss. Does anyone take methotrexate and hydroxychloroquine and has anyone had problems with hydroxychloroquine. Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them. (others may do) and i then can get benefits till i find a job i can do with the ra(i am not doing this just for benefits, i hope people understand that) I have now been on Plaq for just over three years and MTX for just under three years. Also had to have an occupational health meeting today for my job as not worked for 6 months now and hoping they make me redundant as i can't work as a waitress with ra due to pain and flares in my opinion. Why take hydroxychloroquine with methotrexate Hydroxychloroquine MedlinePlus Drug Information, Plaquenil Hydroxychloroquine - Side Effects, Dosage. Why would you take hydroxychloroquine and mycophenolateHydroxychloroquine apsCan i take plaquenil wiDoes plaquenil interact with gerd OBJECTIVE To examine the bioavailability of methotrexate MTX in the presence of hydroxychloroquine HCQ, and vice versa, to determine a possible pharmacokinetic explanation for the observation that combination treatment of rheumatoid arthritis with MTX and HCQ has been shown, clinically, to be more potent than MTX used alone. Combination therapy with methotrexate and hydroxychloroquine.. Does anyone know if hydroxychloroquine. - HealthUnlocked. Hydroxychloroquine Side-effects, uses, time to work. I started on Hydroxychloroquine and prednisone at the end of December. Just saw rheumy yesterday because the prednisone wasn't having any affect on 20 mg/day and my rheumy didn't want to increase the prednisone any higher. So she has put me on methotrexate. She said I can take the dose all at. The most common side effects are fatigue a day or two after you take methotrexate, which is why I suggest taking it at night,” he says. “Also gastrointestinal issues. Your stool may be loose, or you may feel queasy or nauseated for a day or two after. Ask your doctor if it’s OK to take methotrexate and folic acid on the same day, because there's no one-size-fits-all guideline. Always make sure you take methotrexate exactly as prescribed, and watch out for side effects.