Chloroquine volume of distribution

Discussion in 'Trust Pharmacy Canada' started by Manix, 22-Feb-2020.

  1. HeebyWawgab Moderator

    Chloroquine volume of distribution


    If you believe Wordfence should be allowing you access to this site, please let them know using the steps below so they can investigate why this is happening. , also known as apparent volume of distribution) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma.) is possible, and would indicate that the drug is highly distributed into tissue.

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    Oct 25, 2012 The drug is extensively distributed, with a volume of distribution of 200 to 800 L/kg when calculated from plasma concentrations and 200 L/kg when estimated from whole blood data concentrations being 5 to 10 times higher. Chloroquine is 60% bound to plasma proteins and equally cleared by the kidney and liver. Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation 4. The drug has an apparent volume of distribution of 116-285 L/kg in healthy adults. Animal studies indicate that concn of chloroquine in liver, spleen, kidney, and lung are at least 200-700 times higher than those in plasma, and concentration of the drug in brain and spinal cord are at least 10-30 times higher than those in plasma.

    Volume of distribution may be increased by kidney failure (due to fluid retention) and liver failure (due to altered body fluid and plasma protein binding). The initial volume of distribution describes blood concentrations prior to attaining the apparent volume of distribution and uses the same formula. In rough terms, drugs with a high lipid solubility (non-polar drugs), low rates of ionization, or low plasma protein binding capabilities have higher volumes of distribution than drugs which are more polar, more highly ionized or exhibit high plasma protein binding in the body's environment.

    Chloroquine volume of distribution

    The pharmacokinetics of three multiple dose regimens of., Chloroquine & Hydroxychloroquine supporting chemo.

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  4. Drugs that have a volume of distribution 7 4 L or less are thought to be confined to the plasma, or liquid part of the blood. If the volume is between 7 4 and 15 7 L, the drug is thought to be distributed throughout the blood plasma and red blood cells.

    • Understanding Volume of Distribution – Certara.
    • Chloroquine C18H26ClN3 - PubChem.
    • Chloroquine - Wikipedia.

    Both hydroxychloroquine and chloroquine have a large volume distribution and a long half-life, consistent with their slow onset of action and prolonged effects after drug discontinuation. Infusion 155 mg, demonstrated a half-life of about 40 days and a large volume of distribution. Peak blood concentrations of metabolites were observed at the same time as peak levels of hydroxychloroquine. In small children, the ingestion of 1-2 tablets of chloroquine is a potentially life-threatening ingestion. Chloroquine is on the list of ‘two pills that can kill‘ toddlers. The worst case scenario is an ingestion of 310mg/15kg = ~21 mg/kg. In general 10mg/kg is considered toxic, with increasing mortality at doses 30mg/kg.

     
  5. Swit4 Guest

    Background: The American Academy of Ophthalmology recommendations on screening for chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Hydroxychloroquine Plaquenil Toxicity and Recommendations. Plaquenil hydroxychloroquine sulfate dosing, indications. Hydroxychloroquine Side Effects, Dosage, Uses, and More
     
  6. Kubanmedia Moderator

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