Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Chloroquine and proguanil malaria tablets Hydroxychloroquine and trametinib Sometimes mistaken for a retina problem, ethambutol toxicity causes painless loss of central or paracentral vision when the drug damages the optic nerve, which can lead to an optic neuropathy that is symmetric and usually bilateral, said Dr. Shah. Other symptoms may include photophobia or poor dark adaptation. Testing. However, peripheral neuropathy may also be non-symmetrical or more sporadic, affecting patches of areas in the body. This can result from vasculitis, or inflammation of the blood vessels. Symptoms of Neuropathy in Lupus. Symptoms of peripheral neuropathy from lupus can range from mild to serious and mainly affect the hands, feet, legs or arms. Plaquenil Hydroxychloroquine Used for Rheumatological conditions rheumatoid arthritis or lupus. Ocular side effects include blurred or distorted vision, decrease in color vision, blind spots, changes in the central visual area macula, and halos around lights. While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Plaquenil and optic neuropathy Optic neuritis - Symptoms and causes - Mayo Clinic, Lupus and Nerve Damage Plaquenil for sclerodermaPrimaquine chloroquine dosageTapering off hydroxychloroquine Optic nerve vasculopathy and plaquenil illinwithoutacause after suffering from fatigue, eye pain, vision changes, headaches, muscle twitches and other neurological symptoms, i finally got in to see a neuro-ophthalmologist who noted that the arteries feeding my optic nerves were small than he would expect for someone my age 42. Optic nerve vasculopathy and plaquenil - Autoimmune Disorders.. High Risk Medications - Optic One Eye Care Centers of Spokane. Chloroquine and Hydroxychloroquine Toxicity Practice.. Plaquenil Toxicity Plaquenil hydroxychloroquine is a medicine commonly used to treat patients with systemic lupus erythematosus and rheumatoid arthritis. After prolonged use, it can sometimes damage the macula and cause central vision loss. Problems That Can Cause Optic Neuropathy Almost any underlying, chronic condition, injury, or toxin can lead to nerve damage in the eyes. It is important to know what your risks are, so if you begin to experience changes to your vision, you can visit your eye doctor immediately and discuss the potential causes of your vision issues. Ethambutol is associated with optic or retrobulbar neuritis, affecting one or both eyes. An unusual form of the toxicity causes peripheral constriction of the visual field. Monthly ophthalmic exams are recommended for doses of ethambutol exceeding 15 mg/kg/day. Fluoroquinolones are associated with side effects not seen in other classes of antibiotics. Topical administration may cause precipitates in the cornea and, possibly, uveitis.