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Retnio A Micro gel 0.05% is a topical cream which is applied on the skin to treat acne. The active ingredient of the brand Retin A Micro gel is Tretinoin which is a retinoid. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Tretinoin belongs to a class of medications called retinoids. Read the Patient Information Leaflet if one is available from your pharmacist. Consult your doctor or pharmacist if you have questions. Gently clean the affected skin with a mild or soapless cleanser and pat dry. Use your fingertips to apply a small amount of medication (about the size of a pea) in a thin layer, usually once daily at bedtime or as directed by your doctor. A gauze pad or cotton swab can be used to apply the liquid. For some preparations, you should wait 20-30 minutes after cleaning your face before applying this medication. Consult the label directions, the Patient Information Leaflet, or your pharmacist if you have any questions. Do not apply to the inner lip area or inside the nose/mouth. Retin-A and Retin-A Micro are both topical prescription medications that your dermatologist may prescribe to treat your acne. Because they have nearly identical names and are manufactured by the same company, you may wonder if they're the same medication. Tretinoin is a topical retinoid, meaning it's a medication derived from vitamin A. Other topical medications that contain tretinoin include Avita, Altinac, Tretin-X, Renova (mainly prescribed as an anti-wrinkle medication), and Ziana. Because they contain the same active ingredient, Retin-A and Retin-A Micro work in essentially the same way. Both medications work to speed up cell turnover rates. Simply put, they make dead skin cells shed more quickly and effectively than they would on their own. 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