How it works Accutane reduces the amount of oil produced by the skin that leads to hardening of the skin surface. The capsule is to be taken twice a day with a full glass of water, milk or any non alcoholic beverage. Guidelines for Usage Follow the dosage instructions provided by your doctor or as mentioned in the instruction booklet/product label. Take care that you swallow the capsule whole without breaking, crushing or chewing it unless you have been advised accordingly. Doctors recommend that you swallow the whole tablet/capsules with a glass of water unless it is specified that it can be broken or chewed. NOTE: Use only if prescribed to you and intended for your use. Accutane must be used in a cycle with a 2 month rest period after using the drug. Even during this off period, your acne will continue to get better. And after the 2 month rest period, if you still have severe acne, then inform your doctor who may prescribe a second course of treatment or a longer rest period. 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