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    This study illustrates development and validation of a simple high performance liquid chromatographic method for the simultaneous determination of metformin hydrochloride and angiotensin-converting enzyme inhibitors (captopril, lisinopril, and enalapril) in bulk dosage form and their application in pharmacokinetic studies. The quality resolute chromatogram was obtained by using a Purospher® Star RP-18 endcapped (250 × 4.6 mm id) column as stationary phase while acetonitrile-water (v/v) as mobile phase, adjusted to p H 3.0 with phosphoric acid. Lisinopril/hydrochlorothiazide is a prescription drug. In some cases, they may not be available in every strength or form as the brand-name drug. Lisinopril/hydrochlorothiazide is available as the brand-name drug Zestoretic. Generic drugs usually cost less than the brand-name version. Lisinopril/hydrochlorothiazide is a combination of two drugs in a single form. It’s important to know about all the drugs in the combination because each drug may affect you in a different way. Lisinopril/hydrochlorothiazide may be taken in combination with beta-blockers, angiotensin receptor blockers, calcium channel blockers, and diuretics to treat high blood pressure. It’s usually given when one medication isn’t enough to control your blood pressure. Lisinopril belongs to a class of drugs called angiotensin-converting enzyme (ACE) inhibitors.

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